Analysis of Host Immunological Response of Adenovirus-Based COVID-19 Vaccines

During the SARS-CoV-2 global pandemic, several vaccines, including mRNA and adenovirus vector approaches, have received emergency or full approval. However, supply chain logistics hampered vaccine delivery, which is impacting mass vaccination strategies. Recent studies identified different strategies for dose administration so that constraints issues are diminished. These include increasing time between consecutive doses in a two-dose regimen reducing dosage of second dose. We consider both these mathematical modeling study non-replicating viral this work. investigate impact prime-boost by quantifying their effects on immunological outcomes based simple system ordinary differential equations. The boost administered either at standard (SD) 1000 low (LD) 500 250 particles. Results show dose-dependent immune response activity. Our model predictions stretching interval to 18 20, an SD/SD SD/LD regimen, minimum promoted antibody (Nab) will be comparable with neutralizing level measured COVID-19 recovered patients. also stimulated identical high observed clinical trial data. conclude may provide protective capacity, allow conservation doses.